Like previous historical epochal transitions such as the Renaissance and the Great Enlightenment, humanity is poised at the threshold of a "Great Transition" which will profoundly shape human civilization for the next several hundred years. Resilience guiding principles and tested / validated implementation frameworks can serve as the basis for managing the transition and guiding our safe passage to our collective future. Resilience as a way of thinking and acting is more than just surviving, it is also about thriving.